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Stem cells cause cancer

lfbno7 posted on Nov 16, 2008 | views: 151 | Tags: Science, Stem Cells and Cancer, wow gold, soulcast, stimulate my own stem cells
They say that stem cells cause cancer. What does that mean? Does it mean that people who undergo stem cell remedies end up with cancer because of the stem cells? Does it mean that our own stem cells that are still in our bodies are responsible for the growth of cancer? Does it mean both? Does it mean that we can't control stem cells and it's a dead end for medical research? Who knows something.

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  • Lucytorial said on Nov 16, 2008....
    Lenny,
     
    Stem cells are the main building blocks of life.  These cells can in plain speak turn into any part of the human body/blood system/muscles/nerves etc.
     
    Stem cells I suppose can be said to be the source of cancer, some cancers anyway those that are not genetic.  Stem cells can become infected with cancer, they then move rapidly through a humans body migrating to say livers, or the lymphatic system, or bones, etc.
     
    They use stem cell transplants to push out some cancers, its like an auto immune boost.  Some can be autologis (stems cells from the same person) others are external, which means that you need to share certain traights with the donor (very difficult to find)
     
    Stem cells can be controlled... more cleaned Lenny, they can clean stem cells and put them back into the body to do many wonderful things, like cure lymphoma (type of cancer) and other illnesses, the research is still very new and many people do not believe we should be able to use stem cells from placenta donations.. the cord of a new baby has more stem cells and newer stem cells than an adult, they are easier to deal with.  Embrionic stem cells are also usefull however as I said above many peoples religious beliefs get in the way of helping cure many many diseases, cancer being one of them.
     
    Si in essence, a person who has cancer MAY have their stem cells infected with the cancer which can then spread rapidly.  However stem cells can be collected and then PUT back into a cancer sufferer to cure them or put them into long term remission.

    Any other questions?
  • anonymous said on Nov 16, 2008....
    Despite a steady flow of media hype, yes, non-differententiating embryonic stem cells are unsafe for actual patient treatment at this time, due to oncogenicity (cancer causing) a fact that has been well known for several decades; therefore, implantation of fetal precursor (or progenitor) stem cells (a few generations older than embryonic cells) have been safely used as a treatment for over 75 years; albeit under different names. Fetal precursor stem cells from animals are very effective and safe for patient treatment, with no known antigens, hence no need for any immuno-suppression drugs! Human embryonic stem cells, on the other hand, cannot survive in laboratory conditions except by being grown on a 'feeder' layer of mouse cells, which is why the FDA continues to classify them as 'xeno-transplants', i.e. of animal origin. Hope that helps.
  • Lucytorial said on Nov 17, 2008....
    Anon ~ Good researching... the use of embrionic stem cells though for research is a worthy one.  Just thought I'd add that one into the mix.
  • herry0314 said on Nov 17, 2008....
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  • lfbno7 said on Nov 17, 2008....
    It's good that the ignorant one in the White House is finally halfway out, and medical research can continue without any further nonsense. Hopefully.
  • gcdsocal said on Nov 17, 2008....
    My good friend, E. Michael Molnar MD, will be treating very advanced AIDS patients at six teaching hospitals in Nigeria in early December, 2009. He has had 100% success treating six patients in a trial setting already. Dr. Molnar's success with autism is equally impressive -- ALL WITH FETAL ANIMAL STEM CELLS!
  • hottips4u said on Nov 17, 2008....
    This site I read covers what you asked and provides some interesting insight on the matter  for example :

    Module Map Links Embryonic Stem Cells And Cancer Stem Cells

    ScienceDaily (Apr. 9, 2008) — A new study suggests that a genetic fingerprint associated with normal embryonic stem cells may be important for the development and function of cancer stem cells. The research, published by Cell Press in the April 10th issue of Cell Stem Cell, demonstrates that embryonic stem cells and multiple types of human cancer cells share a genetic expression pattern that is repressed in normal differentiated cells, a finding that may have significant clinical implications for cancer therapeutics.

    "Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness program remains controversial," explains study co-author, Dr. Howard Y. Chang from Stanford University. Dr. Chang, Dr. Eran Segal from the Weizmann Institute in Israel and their colleagues constructed a gene module map to systematically relate transcriptional programs in embryonic stem cells (ESCs), adult tissue stem cells and human cancers.

    The researchers identified two predominant gene modules that distinguish ESCs and adult tissue stem cells. "Importantly, the ESC-like transcriptional program was activated in diverse human epithelial cancers and strongly predicted metastasis and death," says Dr. Segal. Conversely, the adult tissue stem gene module had an opposite pattern, activated in normal tissues relative to cancer and repressed in various human cancers when compared to normal tissues.

    The researchers went on to demonstrate that c-Myc, but not other oncogenes, was sufficient to reactivate the ESC-like program in normal and cancer cells. In primary cells transformed by tumor-inducing genes Ras and I B, c-Myc increased the number of tumor-initiating cells that exhibited key properties associated with cancer stem cells and dramatically increased the frequency of tumor formation in mice.

    These findings suggest that activation of an ESC-like transcriptional program in differentiated adult cells may induce pathologic self-renewal characteristics of cancer stem cells. Further, the map of gene modules may prove to be a valuable tool for establishing improved standards for classifying and defining stem cells by using the expression signature modules as "fingerprints" rather than reliance on just a few molecular markers.

    The researchers include David J. Wong, Stanford University, Stanford, CA; Helen Liu, Stanford University, Stanford, CA; Todd W. Ridky, Stanford University, Stanford, CA; David Cassarino, Stanford University, Stanford, CA; Eran Segal, Weizmann Institute, Rehovot, Israel; and Howard Y. Chang, Stanford University, Stanford, CA.



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  • pusscat said on Nov 17, 2008....
    Thank you hottips for these links.  They mean more to me now than ever before.  There is some incredible research in there.
  • gcdsocal said on Nov 17, 2008....
    With all due respect readers, US researchers are still ten years, at minimum, from treating patients in the US with stem cells. However,animal fetal stem cells have been used in Europe for decades, AND, more effective then autolougus (self) cells! 
     
    These treatments inlcude Type I diabetes, ALS, heart disease, autism, down syndrome, AIDS, Chroyns disease, ED, infertility, bipolarity, Lyme disease, macular degeneration, etc., etc.
     
    The American pharma companies don't want the US public to learn about it.  
  • truthsayer said on Nov 17, 2008....
    Hi guys.  I know that this is a hot topic, and those of us that are not ethical scientists and researchers have little that we can add to such a sensitive topic...so, let me just say this:  From what I have read (and these links are very good, btw) it pretty much boils down to two streams of research or two main branches of treatments.

    1. Learn about my stem cells and how to stimulate my own stem cells to heal, repair and restore normal function to my own body.

    2.  Put someone else's stem cells into my body, and then give me immuno-supressants and/or watch me to see if my own body rejects them, causing abnormal cell growth, or cancer (even if the "risk" may be lessened by growing those stem cells in some animal, for a while, before inserting them into my own body).

    Right?  I mean, at this time...isn't that about right?

    I don't mean to oversimplify the issue, but I do mean to sum things up as simply as I can.  I just want to understand this debate, as best I can, from my own personal frame of reference...just like you do.  I mean, conditions and our knowledge are bound to change, but this is why there is such a debate as to the ethics of it all.

    If there is any actual justice in the world...then what I say counts for "one vote" on this whole debate, so to speak.

    I for one, would prefer that money is spent on research that stimulates my own stem cells.  If I had a choice, God forbid...if I had to have a new kidney, for example...and I had a choice of two lines of treatment: 

    1. The surgeon takes out my own, natural but dysfunctional or even nearly non-functional kidney (hopefully, my physician hasn't waited until my kidney tissue is dead in my own body), and surgically implants the kidney of someone else (knowingly donated, or not).

    ...or...

    2.  My own physicial is current on research and has taken measures before we are at a critical, emergency, or even a planned surgery (which is always intrusive and dangerous, aside from my need of a healthy working kidney)...and he/she is able to provide treatment based on sound research and experimentation, that stimulates my owh healthy stem cells to heal, repair or otherwise restore healthy function to my own kidney(s). 

    I know which one I would choose.  My own body is as unique as yours is.  Each body is similar in function and overall design, but still, infinitely different.  We are always better off learning how to stimulate healing in our own bodies, by our own bodies.  That is why we have stem cells in the first place. 

    Don't you think it would be better to learn about our own bodies stem cells, immune systems (which cancer is a disease of the immune system, btw) and learn about causes and prevention, as well as cures?  Ethical stem cell research should be addressing both of those venues. 

    I don't blame people that cling to the embryonic stem cell research, and enjoy debating it.   I am not even offended that they tend to completely discount my concerns as off-handedly as they dismiss my sound belief in the original perfection of the Creator's creation.  : )

    We just need to understand, once and for all, that it hasn't been a smooth road, and no amount of smoke and mirrors will preclude the ignorance of the wizard forever. That is why we research.  We don't know things.  So we research.  I appreciate that.  We are only learning.  We must choose what we learn, but we are only learning.   I can only appreciate intellectual honesty.  Most of these links (I did not read all of them, however) seem to be pretty transparent. There have been huge problems in the field applications. The stem cells from the cord are totally different,  ethically speaking, from the embryonic stem cell research of course. 

    My own opinion is that our dollars are going to go toward research...no matter what.  If they can spend those dollars in a way that helps my own body to heal, and I don't have to be on a drug "therapy" that suppresses my own healthy immune system so that it cannot do what it was intended to do...that is to fend off and/or destroy foreign tissues and other things it identifies as "invaders" that are introduced into my body...well, then I hardly see that as a cure.  Spend the money on what will help me the most, cost the least and keep me alive, healthy and well for a good, long time into my future ; )

    My oldest daughter's biological father has IGA Nephropathy.  It was not diagnosed until it was too late.  He required a kidney transplant.  His mother gave him her kidney.  He has been on immuno-suppressants ever since, because eventhough his mother's kidney was a gift of life for a season...his own body continually tries to reject it.  I don't know if he, or even if his mother, is still alive.  It's not like we "visit".  But I know that he will spend the rest of his natural life on steroids (and other drug "therapies") that make him weak, puffy, and destroy his bones and other tissue in his own body.  He has to.  He has someone else's tissue in his own body.

    Well, this ended up long.  I am sorry, but then again, I am not.  Make this discussion real for yourselves folks.  Put the names of your own loved ones into the discussion.  Discuss it as if it was all about your daughter, your son, your mother, etc.  Many people have done this...with discussions for and against.  At least it helps to transcend some of the nastiness in the discussion.  If you can honestly say that you would conceive a child only  to use it's "tissue" or cells, to save the life of one of your other children, even if it was only for a while...well, at least you took the time to look into your own soul regarding the matter.

    If I had healthy stem cells, that I could donate to another...I'd do it.  There is some pretty impressive research going on.  Let's just make sure that we don't use this stem cell research as an excuse for our own bad behavior, our own selfishness, or our own short-sightedness.  Okay?

    Gotta love, and love BIG.  Gotta tell yourself and others the truth...all the time, all the time, ALL THE TIME.

    Very important discussion lfbno7.  In spite of your finger-pointing to our current president, President Bush.  He's just a man lfbno7.  The only thing different about him, and you and I, is that we have different security clearances, and we have access to different levels of communication/information/data.  Don't forget that.  It will be the same for President-Elect Obama as well.  Different security clearance and access to different levels of communication/information/data.  The only difference is you and me, is that I pray for and respect both of them now, and always.  : )

    Your neighbor,

    Truth : )   






  • truthsayer said on Nov 17, 2008....
    Hey there gcdsocal!  Nice to meet you.  Do you mean that they are using animal stem cells that are purely animal stem cells?  Not human cells that have "grown" in animals?  Can you please clarify and also, post a few links?  I would be very interested in that.  It seems like there is so much information that is supressed here, by the drug companies and even the AMA.  They think they have a corner on the word "heal", but there are in fact, no medical healings.  Healing is when my own body heals.  They cannot force healing.  It is a natural phenomenon. 

    Anyway, can you tell us and show us more on this?  I am not asking for agreement here.  I am asking for information, for knowledge of the facts, so that I can apply wisdom.   

    Thank you so very much.

    Truthsayer : )
  • gcdsocal said on Nov 17, 2008....

    Again, there are only three sources of stem cells: 1) allo (one species to same species), autologous (your own cells) and xeno (animal cells). All embryonic cells have potential for causing cancer because they are non-differentiating cells. Progenitor stem cells do not cause cancer; PROVIDED they are properly “manufactured/cultured”.

    Progenitor stem cells are the most prolific (greatest efficacy) of all stem cells, while autologous cells have the least efficacy (65 year old stem cells are not as potent as eight week old stem cells!). Assuming fetal cells are manufactured properly, they will be FREE of all known antigens, thus NO NEED to take immune-suppression drugs for the rest of one’s life. Regrettably, organ transplant recipients do not have the luxury.       

    Lastly, progenitor cells “home”! Which quite simply means once injected into the recipient body they immediately migrate to the diseased or damaged organ or tissue from where they came in the donor’s body, e.g. liver-to-liver, retina to retina, etc. If upon arriving at the presumed damaged organ and find no damage, then they are just eventually absorbed into the body harmlessly!

    This is really a very simple process that science tries to make difficult.        

        

     

  • Lucytorial said on Nov 17, 2008....
    Truthsayer ~ You sweetie.
     
    I understand its easier to deal with this topic when its simplified down believe me.

    As for embrionic stem cells well in Australia (the leading researcher for cancers) the reason my husband was able to have a stem cell transplant (autologis) was due to this type of research.

    @ GC ~ Autologis cells are as adept especially in the young which is where they are mainly used today due to the lack of other stem cell therapies.  Its far easier to clean out the stem cells collected and replace them without drug therapy post transplant.
     
    When using stem cells for cancer patients the transplant itself takes appox a year of drug therapy to practically kill the patient, surpess their immune system so much.. while collecting the cells (using many drugs, usualy its a combination and one such drug is GCSF a potent drug which essentially makes the stem cells jump! into the main blood stream for collection, quite a painful experience believe me) and cleaning them they are effectly and efficiently replaced within a period of three months.  Usualy they will store extra collected and cleaned cells for future use however its been shown this is not neccessary for autologis transplants.  Simply it works.  So the cells are stored for further research (by agreement)
  • gcdsocal said on Nov 17, 2008....
    Lucytorial, I think I know your reference point now re cancer treatment viz., stem cell transplantation for diseased organs, etc. Quite simply, stem cells treatments have not been successfull in treating an/or curing cancer to date, other then select cancers of the blood. However, autologous "bone morrow" transplants have been around for some time now, which I suspect is what your husband had done.
     
    Treatment of cancer via stem cell transplantatin is done for the sole purpose of GREATLY enhancing ones immune system, in hopes of successfully fighting off the invading cancer. For you must recognize that stem cell transplantation is only treatment known to man to  DIRECTLY stimulate the immune system, all other treatments, regardless of what they may be, treat via INDIRECT immune stimlulation; hence why there are so many that fail! 
     
          
     
         
  • Lucytorial said on Nov 17, 2008....
    Yes I suppose I should qualify this, my perspective and experience of it.
     
    My husband had an auto stem cell transplant (bone marrow) and he was cured, completely.  To the point of regression back to being fertile again which is a 1 in 100,000 and never happened before in the history of Australian transplants {of this kind}
     
    The reason? we got heavily involved in his treatment regeim and what drugs were going to be used, what kind of chemo combinations, how he was hospitalised, when certain aspects would occurr, we did in other words our research.  Took ownership of the process - which was long, quite long.
     
    Greatly ehancing the immune system in general for his type of cancer is hugely successfull as you may know they don't like to use the cured word.. however in our case they did and continue to do so.
     
    Its most successfull with non hodgkins and hodgkins cancers (including all lymphomas).. hubby was stage 3 quite developed to be honest and it was the last choice, the only thing left to try, the reason we did because he was only 36, young enough to be able to build his system up before it was totally crashed.

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