Joe Langer conducting clinical trials

Estrogen also has been shown to regulate the anagen-telogen cycle (Proc. Natl. Acad. Sci. USA 93[22]:12,525-30, 1996). The higher levels of estrogen during pregnancy cause the hair to grow by increasing the amount of hair in the anagen phase. The hair loss often seen in postmenopausal women is likely the result, at least partially, of the increased amount of hair in the telogen phase.( Joe Langer thorough evaluation)

Joe Langer perform a full evaluation
Joe Langer => More research with topical estrogen: Research shows that topical estrogen acts like oral HRT in preserving skin thickness and increasing collagen and glycosaminoglycans content of the skin. Dr. J.B. Schmidt and colleagues examined the effects of topical 0.01% estradiol and 0.3% estriol, and after 6 months of treatment, the investigators found improvements in skin elasticity, firmness, and wrinkle depth similar to that seen in studies using oral or transdermal HRT (Int. J. Dermatol. 35[9]:669-74, 1996).

Physicians should note that only this hormone replacement therapy (HRT) phase was halted; the estrogen replacement therapy (ERT) phase, showing dissimilar results thus far, continues. (HRT combines estrogen with progestin and is indicated for women who have undergone natural menopause; ERT is an estrogen-only regimen indicated for women whose menopause is surgically induced.)

Joe Langer conducting clinical trials
No risk reduction was evident when multivitamin use was begun after the first month of pregnancy. If these associations are causal, the results suggest that approximately one in four major cardiac defects could be prevented by periconceptional multivitamin use.OBJECTIVE--To examine the relationship between total serum carotenoid levels and the risk of subsequent coronary heart disease (CHD) events.

At any moment, about two per cent of circulating testosterone is "free"�unbound to any protein�and thus biologically active. The patient's free testosterone was a little under the lower limit of normal. ("Normal" testosterone levels refer to what's normal for men in their twenties.) "If I had a magic wand and I could do anything for you, what would it be?" Morgentaler asked.

United Medical Network - AndroGel
"If the answer is yes, that replacement therapy causes heart damage or sparks emergence of prostate cancer, then you will know in six years or so," he says. "But older people in this age group won't wait six to ten years to have solid answers. Clinical practice will move at one rate, and the data will trail."

Prostate cancer. No direct evidence has linked testosterone replacement with increased risk of prostate cancer. But prostate cancers that were not detectable by prostate-specific antigen (PSA) level or digital rectal exam were found by biopsy in 14% with low testosterone levels (JAMA 276[23]:1904-06, 1996).

Joe Langer hormone levels
Joe Langer Endocrinology => Intramuscular injections, particularly favored by bodybuilders and competitive athletes, produce a sharp spike of the hormone, and then a fall, and these fluctuations are often accompanied by swings in mood, libido, and energy. In the late eighties, a transdermal patch was developed, and its use is still widespread. The patch provides safer and steadier dosing, but often causes skin irritation, and sometimes falls off during exercise.

The pharmaceutical industry is, of course, in the business of inventing treatments. Some people wonder whether it may help invent diseases, too. To be treated for andropause, you first need physicians who can confidently make the diagnosis. One of them is Dr. Abraham Morgentaler, the director of Men's Health Boston. He is forty-six years old, with thick black hair and deep-set eyes. Trained as a urologist, he specializes in male sexual dysfunction and infertility.( Joe Langer)

Joe Langer
There's no doubt that the panel reached its conclusions in good faith; the androgen enthusiasts are nothing if not sincere. But it's also the case that a Unimed/Solvay educational grant was the sole source of funding for the Beverly Hills conference. According to Scott Hunt, the Endocrine Society's executive director, Unimed even suggested some of the panel's members.

Research has identified both estrogen and androgen receptors on dermal fibroblasts and epidermal keratinocytes (J. Reprod. Med. 35[11]:1015-16, 1990). Distribution is inconsistent, with a preponderance of estrogen receptors located on skin overlying the female external genitalia, as well as the face, breast, and thigh. The areas of the epidermis found to be most sensitive to estrogen are concentrated in the granular layer, although estrogen-sensitive structures are also present throughout the epidermis, in hair follicles, and the sebaceous glands (Br. J. Dermatol. 117[2]:217-24, 1987).

United Medical Network diagnostic studies
Until then, the attempt to reverse the gradual decline in testosterone levels in aging men can't be considered the treatment of a disorder: it amounts to a vast, uncontrolled experiment, whose consequences remain uncertain. As Hayes says, "It would be a shame to make the same mistakes again."Once again, Viagra comes to the rescue. A new study shows that Viagra in combination with Paxil helps premature ejaculators who have not improved with standard treatment.

Administration of coenzyme Q(10) in conjunction with standard medical therapy has been reported to augment myocardial kinetics, increase cardiac output, elevate the ischemic threshold, and enhance functional capacity in patients with congestive heart failure. The aim of this study was to investigate some of these claims. Seventeen patients (mean New York Heart Association functional class 3.0 +/- 0.4) were enrolled in an open-label study.

Joe Langer research
Joe Langer cardiovascular disease => There was no evidence that testosterone increased skeletal muscle strength or bulk, or that it changed plasma levels of proinflammatory cytokines, Dr. Jones saidIt goes by many names. "Male menopause" is perhaps the most popular, but "andropause" is the term that many doctors favor, and PADAM ("partial androgen deficiency in aging men") has its partisans, too. The condition may afflict millions of Americans, and, if they do not yet recognize the symptoms, a public-awareness campaign has been launched to help them.

�Many men don't seek out medical attention for health problems in the early stage,� Dr. Petak said. �And they don't feel comfortable talking about the major symptom, loss of libido.� Even if patients do mention decreased sexual urge, physicians might be more likely to prescribe Viagra than to perform a full evaluation.

Joe Langer benefits
This is where marketing and medical science may part ways. Pharmaceutical companies often obtain F.D.A. approval of a new product for a niche population with a relatively rare disease, hoping to expand later to a larger and more profitable market. Once a drug is approved for sale, a physician can legally prescribe it for any clinical condition he thinks would benefit from it.

If you're hoping to expand the medical "indications" for a drug regimen, there are few greater boons than the endorsement of a major medical society. Unimed's andropause campaign won a considerable victory when the Endocrine Society�a prestigious organization of hormone specialists�convened its First Annual Andropause Consensus Conference, in April of 2000, just six weeks before AndroGel came on the market.( Joe Langer hormone replacement)

United Medical Network testosterone-replacement therapy
Several years ago, Dr. Crowley realized that, in order to study hypogonadal men, he needed a clear definition of normal testosterone levels. So he inserted catheters into the veins of healthy young subjects in their twenties and drew blood samples every ten minutes in the course of twenty-four hours. He still sounds amazed by what he found.

Cardiovascular disease (CVD), particularly in the form of coronary artery disease, is the leading cause of death in the United States. Research in the past 10 years links pathogenic low-density lipoprotein (LDL) modification to oxidation damage by free radicals. This review summarizes the major findings of CVD-related epidemiologic research and clinical trials conducted in the past 5 years on vitamins A, C, and E. Vitamin supplementation behaviors are discussed.

Joe Langer the risks of cancer
Joe Langer laboratory findings => Reversing a long-standing anti-vitamin policy, The Journal of the American Medical Association today is advising all adults to take at least one multivitamin pill each day. Scientists' understanding of the benefits of vitamins has rapidly advanced, and it now appears that people who get enough vitamins may be able to prevent such common chronic illnesses as cancer, heart disease and osteoporosis, according to Drs. Robert Fletcher and Kathleen Fairfield of Harvard University, who wrote the new guidelines.

CONCLUSIONS--The LRC-CPPT participants with higher serum carotenoid levels had a decreased risk of incident CHD. This finding was stronger among men who never smoked.Despite major advances in treatment congestive heart failure (CHF) is still one of the major causes of morbidity and mortality. Coenzyme Q(10) is a naturally occurring substance that has antioxidant and membrane stabilizing properties.

Joe Langer thorough evaluation
The 958 case infants with nonsyndromic cardiac defects were actively ascertained from multiple sources. The 3,029 infants without birth defects (control infants) were selected from birth certificates by stratified random sampling. Periconceptional multivitamin use, defined as reported regular use of multivitamins from 3 months before pregnancy through the first 3 months of pregnancy, was contrasted with no use during the same time period. Periconceptional multivitamin use was associated with a reduced risk for nonsyndromic cardiac defects in the offspring (odds ratio (OR) = 0.76; 95% confidence interval (Cl): 0.60, 0.97). The risk reduction was strongest for outflow tract defects (OR = 0.46; 95% Cl 0.24, 0.86) and ventricular septal defects (OR = 0.61; 95% Cl: 0.38, 0.99).

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